Natural Epithelial Nitric Oxide

I need a comparison based on scientific literature review of the following natural endothelium nitric oxide synthase NOS-3 activators, for purposes of men’s health and vascular health, in particular when supplied along with NO precursors such as arginine or citrulline.

– pycnogenol
– quercetin
– apigenin
– grape seed extract (procyanidins)
– red ginseng extract (RG3)

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Which of them inhibit NOS-2 while activating NOS-2?
Which activate both? Read more information at

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Research for available scientific data and create a comparison table of the daily amounts in mg of each substance (as extract or isolate) supplemented to reach comparable NOS-3 activation and nitric oxide production effect. (for example, as measured by nitric oxide metabolites in the urine) or any other method.

What is the risk of excessive peroxinitrite free radical formation, when supplying these NOS activating agents, in what doses, and how it may be countered or avoided?


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